Beilstein J. Org. Chem.2022,18, 486–496, doi:10.3762/bjoc.18.51
tertiary amine sites were found to be crucial for achieving efficient activation and stereocontrol. As shown in control experiments, catalysis with the acyclic analogues having the same structural motifs were non-selective.
Keywords: chiral macrocycles; cooperativeasymmetriccatalysis; decarboxylative
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Graphical Abstract
Figure 1:
Design of PKS-inspired multifunctional amino-thiourea macrocycle catalysts.